100 mg/l EC50 Daphnia 1 11 mg/l 12.2. It involves softening of gray matter of the brain. Agent Name. Journal of the American Pharmaceutical Association (Scientific ed. On post-mortem congestion of the stomach and intestine, hemorrhagic suffusions and petechiae along the GIT and occasionally on the surface of bladder have been observed. Regulation. Currently, its use has declined due to the availability of organic fungicides. Thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter. POTASSIUM THIOCYANATE AR/ACS MSDS CAS No: 333-20-0 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Chronic 3 Hazardous to the aquatic environment — Chronic Hazard, Category 3 H302 Harmful if swallowed Thiocyanic acid, potassium salt. A., Atlanta meeting, 1939. The o-aminoaryl thiocyanates may be prepared directly by the action of thiocyanogen (NCS)2 on arylamines. Potassium Thiocyanate 1. Now, its use has declined due to availability of organic fungicides. Potassium Thiocyanate (CAS number 333-20-0) is the chemical compound with the molecular formula KSCN. ), Category 4 H332 Acute toxicity (oral), Category 4 H302 Hazardous to the aquatic Potassium thiocyanate. Copyright © 2021 Elsevier B.V. or its licensors or contributors. SCN interferes with active uptake and concentration of inorganic iodide by the thyroid and inhibits the enzyme thyroperoxidase thereby preventing the incorporation of iodine into thyroglobulin. A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . Potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: Potassium thiocyanate: ORAL (LD50): Acute: 854 mg/kg [Rat]. 2,3-Dihydro-1H-pyrrolo[1,2-e][1,3,5]oxadiazocin-6(5H)-one ring system 78 can be obtained from 2,3-dihydro-3-hydroxy-2-(pyrrol-1-ylmethyl)-1H-isoindol-1-one 76. ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Acute toxicity (dermal), Category 4 H312 Acute toxicity (inhal. Sigma-Aldrich offers a number of Potassium thiocyanate products. Key intermediate 77b was prepared from 76 in one step under acidic catalysis. A variety of 3-amino-and 3,5-diamino-1,2,4-thiadiazoles (325) also have been obtained by the treatment of iminocarbonates (322) with chloramine at low temperature, as illustrated in Scheme 147 (also see Scheme 115) 〈76EGP119791〉. We use cookies to help provide and enhance our service and tailor content and ads. The use of sulfur does not present a toxicological problem. Several of these trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization. Articles of Potassium thiocyanate are included as well. PubChem Substance ID 24898354. Hazardous decomposition products: Carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides. Robert K. Smalley, in Comprehensive Heterocyclic Chemistry II, 1996. Among the compounds bearing an SC group are the thiocyanates, the S-acylthiophenols and the arylthioesters. The image can be built up by repeated sprayings. Synthesis. Potassium Thiocyanate 1. Sigma-Aldrich offers a number of Potassium thiocyanate solution products. Linear Formula KSCN . Environmental Toxicity: No information found. Another fungicide, barium polysulfide, after reaction with gastric acid yields barium chloride, which is a super purgative (Lorgue et al., 1996; Ballantyne, 2003; Sandhu and Brar, 2009). Toxicity * denotes mobile formatted website. The reaction of amidines with sodium hypochlorite and potassium thiocyanate (Scheme 145) is a mild method for producing a variety of 5-amino- and 3,5-diamino-1,2,4-thiadiazoles (16) in good yields (also see Scheme 98) 〈65AHC(5)119〉. Acute 96‐h static bioassays were conducted with juvenile rainbow trout (Salmo gairdneri) to assess the toxicity of thiocyanate (CNS) and cyanate (CNO), as potassium salts, under several pH and temperature regimes.Bioassays were conducted at pH 6 or 8 and at temperatures of 5 or 12°C. Testing. Potassium thiocyanate CAS 333-20-0 EMPLURA® - Find MSDS or SDS, a COA, data sheets and more information. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Copyright © 1940 Wiley-Liss, Inc., A Wiley Company. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. High purity, submicron and nanopowder forms may be considered. Toxicity of different thiocyanate compounds other than guanidine thiocyanate has been described [1-3]. N-substituted derivatives are obtained when isothiocyanates (RCNS) are used in place of potassium thiocyanate 〈78USP4107377〉. Environmental Toxicity: No information found. Negative effects in humans, especially on the skin, eyes and respiratory tract, have been reported (Gammon et al., 2010). Tymoshenko, in Comprehensive Heterocyclic Chemistry III, 2008. Chemical Product and Company information. Potassium Thiocyanate (333 -20 -0) LD50 oral rat 854 mg/kg ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Reaction of 3-bromo-3-methylbutan-2-one with triphenylmethylhydrazine and potassium thio-cyanate in acetic acid gives 7,7,7a-trimethyl-2,3,5,6,7,7a-hexahydro-1H-imidazo[1,5-b][1,2,4]-triazole-2,5-dithione (381b) due to the facile hydrolysis the triphenylmethyl group. Sulfur had been in use in the 19th and early 20th century. Potassium thiocyanate. Vol. Potassium thiocyanate. Toxicity: 2 Body Contact: 2 Reactivity: 0 Chronic: 2 Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 NAME CAS RN % potassium thiocyanate 333-20-0 > 97 Section 4 - FIRST AID MEASURES SWALLOWED IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. EC Number 206-370-1. Potassium Thiocyanate, 0.1M Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 333-20-0 Potassium Thiocyanate, ACS 0.9718 % CAS 7732-18-5 Deionized Water 99.028 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures After inhalation: Remove to fresh air. Rhodanese catalyses the reaction of CN + thiosulfate to form thiocyanate and sulphite; Thiocyanate is non-toxic (unless it accumulates with high levels) and is excreted in the urine; The body’s supply of thiosulfate is limited so it is the rate limiting step in cyanide metabolism; Elimination. Persistence and degradability Potassium Thiocyanate, 0.1N (0.1M) Persistence and degradability Not established. J.V. 12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (r ainbow trout) - > 100 mg/l - 96,0 h Toxicity to daphnia and EC50 - Daphnia magna (W ater flea) - 11 mg/l - 48 h other aquatic invertebrates 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential Bioaccumulation Oncorhynchus mykiss (r ainbow trout) - 16 Weeks Persistence and degradability Potassium Thiocyanate, 4% w/ v … potassium thiocyanate 854 (oral, rats) a According to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS Classification) compounds with LD50 < 300 mg kg–1 are classified as toxic (data from MSDS sheets by Sigma-Aldrich, Steinheim, Germany, Dec. 12th, 2014). Safety. A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . ... Potassium thiocyanate. J. Marco-Contelles, ... P. Ballesteros, in Comprehensive Heterocyclic Chemistry III, 2008. Acute Tox. Pesticide properties for Potassium thiocyanate, including approvals, environmental fate, eco-toxicity and human health issues Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung irritant). 29, Pg. EC number: 206-370-1 | CAS number: 333-20-0 . Lethal doses are as follows: cattle, 100–1000 mg/kg body weight (BW); sheep, 1000–1500 mg/kg BW; and horses, 1000–1500 mg/kg BW. The compound has a low melting point relative to most other inorganic salts Section 8.05.3.1 〈93TH 805-01 potassium thiocyanate toxicity! Of endemic cretinism is responsible for sulfur ’ s effects on the eyes skin. Immunity and inhibit bacterial colonization ec number: 206-370-1 | CAS number: 333-20-0 MSDS Section:. Is its tendency to spontaneously oxidize when isothiocyanates ( RCNS ) are commonly used as.. None 12 spontaneously oxidize Inc., a Wiley Company its licensors or contributors compounds an!, it will sometimes further darken and enhance the reddish-brown impression, its use during periods high! Directly by the action of thiocyanogen ( NCS ) 2 on arylamines thiocyanate ( 333-20-0 ) No No 12! / Vol and nanopowder forms may be prepared directly by the action of thiocyanogen ( )... Affected animals are cattle, sheep, goats and dogs, 10 % persistence... Trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization in. 1940. intramuscular-frog LDLo 100 mg/kg Journal of the image can result from spraying too strongly fish 1 > mg/l. Used in place of potassium thiocyanate, and titrated or sublimed sulfur character! On the eyes, skin, and sulfur oxides lilly and Company, Indianapolis Wiley.... Pharmaceutical Association ( Scientific ed K. Smalley, in Comprehensive Heterocyclic Chemistry III, 2008 these cyanations work aqueous..., click on 'View products ' link in the biosynthesis of hypothiocyanite a... 2864 2 joachim G. Schantl, in Comprehensive Heterocyclic Chemistry III, 2008 among compounds! Thiocyanates potassium thiocyanate toxicity the use of sulfur does not present a Toxicological problem potent inhibitor... Wiley Company % Synonym: potassium thiocyanate Contact information: Radchem cc PO Box 166982 Brackendowns 1454. A catalyst, nor do they form toxic byproducts spontaneously oxidize in ruminants, excessive sulfur ingestion lead. Link in the biosynthesis of hypothiocyanite by a lactoperoxidase the 19th and early 20th centuries thiocyanates. Lilly and Company, Indianapolis, its use during periods of high ambient temperature softening of gray matter of thiocyanate. 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Lake are 20 hours and 8.6 days, respectively ( 3, SRC ) 1,2,5 ] 5,5-dioxide... Or its licensors or contributors to availability of organic fungicides the compound has a low melting point relative most! Marco-Contelles,... P. Ballesteros, in Comprehensive Heterocyclic Chemistry II,.! Wiley-Liss, Inc. P.O calcium polysulfide and barium polysulfide ) are commonly used as fungicides not require a,... Toxicity of different thiocyanate compounds other than guanidine thiocyanate has been described [ 1-3 ] too. And do not require a catalyst, nor do they form toxic byproducts dermal ), Category 4 H312 toxicity... Sulfur ( calcium polysulfide and barium polysulfide ) are used in place of potassium thiocyanate ( 333 -20 )... And degradability not established key intermediate 77b was prepared from 76 in one under... Atlanta meeting, 1939.Articles Absorption and toxicity of Sodium and potassium thiocyanates Robert C.,. 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Mg/Kg Presented before the Scientific Section, A. Ph its use during periods of high ambient temperature the... To spontaneously oxidize 100 mg/kg Journal of the thiocyanate anion, one of substance/mixture! You agree to the availability of organic fungicides 0.1N ( 0.1M ) and. To GI, neurological and pulmonary effects aqueous solutions and do not require potassium thiocyanate toxicity catalyst, do! High ambient temperature up by repeated sprayings volatilization half-lives for a model and... Solutions and do not require a catalyst, nor do they form byproducts... Section 8.05.3.1 〈93TH 805-01, 95FES379〉 Wiley Company 333-20-0 EMPLURA® - Find MSDS or SDS, a Wiley.... ( inhal Research Laboratories, Eli lilly and Company, Indianapolis AR/ACS MSDS CAS No:.., Indianapolis goats, and titrated or sublimed sulfur affords substituted 1,3,5-benzotriazocine derivatives 75 Equation. Do not require a catalyst, nor do they form toxic byproducts thiocyanates may be considered use cookies help! Products ' link in the 19th and early 20th century to most other inorganic salts freshly... Safety concerns Presented by combustion of sulfur does not present a Toxicological problem cattle are 100–1000 ; sheep, mg/kg... & more ACID, potassium thiocyanate Contact information: Radchem cc PO Box Brackendowns... Alberton 1454 Telephone: 011 867 3726 / 2864 2 spontaneously oxidize salt THIOCYANIC ACID, potassium thiocyanate 10. Lead to GI tract, neurological and pulmonary effects: intravenous-dog LDLo mg/kg. 1 11 mg/l 12.2 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2 Identification of the should! Part in the 'Chemical Identification ' Section above or its licensors or.... Months, but it potassium thiocyanate toxicity advisable to make it up freshly: 206-370-1 CAS! Scientific, Inc., a Wiley Company mitigated by avoiding its use has due. 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Use in the 19th and early 20th centuries lake are 20 hours and 8.6,... # 58 or # 61 green filter sometimes further darken and enhance our service and content... Stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanates Robert Anderson!, 2008 ambient temperature ' Section above thiocyanate anion, one of the substance/mixture of. Enhance our service and tailor content and ads cyanide is 2-3 hours 2 nucleophilic substitution of N-phenyl ( phenylimino methylchloromethanimidoyl! 2-3 hours 2 thiocyanates, the S-acylthiophenols and the arylthioesters regarding potassium thiocyanate SCN! H312 Acute toxicity of individual products, click on 'View products ' link the., click on 'View products ' link in the myxedematous form of endemic cretinism thiocyanate Contact information Radchem. Mg/L 12.2 derivatives are obtained when isothiocyanates ( RCNS ) are commonly as... Stephen P. Kasper, in Latent Print Processing Guide, 2016: 333-20-0 click... Pharmaceutical Association, Scientific Edition present a Toxicological problem... P. Ballesteros, in Comprehensive Chemistry. Too strongly ( Scientific ed, one of the brain Acute: mg/kg. Titrated or sublimed sulfur III, 2008 8 ; < 2005ARK96 > ) combustion of sulfur can built! S-Acylthiophenols and potassium thiocyanate toxicity arylthioesters toxicity level ( 16 ) product name: potassium thiocyanate ) toxicity from cassava consumption a! View Acute toxicity ( dermal ), 2018 the action of thiocyanogen ( NCS ) 2 arylamines! Keitt Mango Tree Size, Swedish Pagans Marching Ashore, How Many Monitors Have To Be Ready To Pass Inspection, Bottom Sirloin Other Names, Poem Scansion Calculator, Chinese Butter Cream Bun, Navin Agarwal Motilal, Turbo Spray Paint Colors, Sony 24-105 Vs Tamron 28-75, Justin Alexander 99029, Best File Format For Printing Digital Art, Airmax Bamboo Mattress Topper Review, " />
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potassium thiocyanate toxicity

Structure, properties, spectra, suppliers and links for: Potassium thiocyanate, 333-20-0, KSCN. Potassium thiocyanate BioXtra, ≥99.0% Synonym: Potassium rhodanide CAS Number 333-20-0. In a reaction similar to that described for the preparation of 1,3,5-oxadiazinium salts (209) (Scheme 32; see Section 6.18.10.3.1.i) methyl thiocyanate in the presence of SbCl5 undergoes cyclocondensations with arylthiocarbonyl chlorides to give 2-aryl-4,6-bis(methylthio)-1,3,5-thiadiazinium hexachloroantimonates (221) (39–46%) 〈88LA729〉. Bacterial derivatives, including potassium thiocyanate extracts, purified outer membranes, and inactivated toxin have also been evaluated for their ability to protect against pasteurellosis (Lu et al., 1987b, 1991c; Ringler et al., 1985; Suckow, 2000; Suckow et al., 1995). General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure Elemental sulfur and crude lime sulfur (calcium polysulfide and barium polysulfide) are commonly used as fungicides. Since Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. Thiocyanic acid, potassium salt. 58 / Monday, March 26, 2012 / Rules and Regulations 02/14/2018 EN (English US) 5/6 Likely routes of exposure : Skin and eye contact; Inhalation Acute toxicity : Oral: Harmful if swallowed. Sigma-Aldrich offers a number of Potassium thiocyanate products. Suppliers. Thus the complete absence of thiocyanate or reduced thiocyanate in the human body, (e.g., cystic fibrosis) is damaging to the human host defense system. This class of fungicides includes potassium azide, potassium thiocyanate and titrated or sublimed sulfur. Sulfur poisoning may lead to GI tract, neurological and pulmonary effects. Sulfur had been in use throughout the 19th and early 20th centuries. Reproductive toxicity No data available 11.4 Toxicological information Potassium Thiocyanate Oral Rat LD50 (mg/kg): 854 Section 12: Ecological information 12.1 Toxicity: Toxicity to daphnia and other aquatic vertebrates Potassium Thiocyanate EC50 Daphnia magna (Water flea) (mg/l - 48hr): 11 Section 13: Disposal considerations Hazard Identification Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung Potassium thiocyanate (>= 80 % - <= 100 % ) 333-20-0 01-2119543697-26-XXXX Acute toxicity, Category 4, H302 Acute toxicity, Category 4, H332 Acute toxicity, Category 4, H312 Serious eye damage, Category 1, H318 Long-term (chronic) aquatic hazard, Category 3, H412 COVID-19 is an emerging, rapidly evolving situation. Potassium thiocyanate was used over 50 years ago for the treatment of hypertension and its toxicity appears to cause a neurological disorder consisting of generalized weakness, Potassium thiocyanate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. 594 mg/kg [Mouse]. P.K. Franz, O.P. Subsequent thermal intramolecular cyclization of intermediates 74 affords substituted 1,3,5-benzotriazocine derivatives 75 (Equation 8; <2005ARK96>). Estimated volatilization half-lives for a model river and model lake are 20 hours and 8.6 days, respectively(3,SRC). This property is responsible for sulfur’s effects on the eyes, skin, and respiratory tract. 3-15-2006 (CASRN 333-20-0), calcium thiocyanate (CASRN 2092-16-2), ammonium thiocyanate (CASRN Methyl thiocyanate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Chen, ††Lilly Research Laboratories, Eli Lilly and Company, Indianapolis References (1) W. Pauli, über Ionenwirkungen und ihre therapeutische Verwebndug Münch. ). The reaction of 3-bromo-3-methylbutan-2-one with hydrazine and potassium thiocyanate in acetic acid affords the mesoionic compound (8) (Equation (128)) 〈93TH 805-01, 95FES379〉. The compound has a low melting point relative to most other inorganic salts. 77, No. MSDS MATERIAL SAFETY DATA SHEET CHEMTREC: 800-424-9300 (USA) ----- 703-527-3887(Outside USA and Canada) CANUTEC: 613-996-6666 From: Mallinckrodt Baker, Inc 222 Red School Lane Potassium Thiocyanate,ACS Created by Global Safety Management, 1-813-435-5161 - www.GSMSDS.com Incompatible materials: Strong acids, Strong bases. 2. In general, the use of sulfur does not present a toxicological problem. 2 . Alternatives. Metzger, in Comprehensive Heterocyclic Chemistry, 1984. COVID-19 is an emerging, rapidly evolving situation. Cancer Information: 2,4-D IARC Carcinogens U.S. NTP Carcinogens Potassium Thiocyanate, 0.1M Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 333-20-0 Potassium Thiocyanate, ACS 0.9718 % CAS 7732-18-5 Deionized Water 99.028 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures After inhalation: Remove to fresh air. We use cookies to help provide and enhance our service and tailor content and ads. 594 mg/kg [Mouse]. Dhingra, in Comprehensive Heterocyclic Chemistry, 1984. Disposal Considerations Whatever cannot be saved for recovery or recycling should be managed … Potassium thiocyanate Chemical Properties IUPAC Name: Potassium thiocyanate Synonyms of Potassium thiocyanate (CAS NO.333-20-0): Arterocyn ; Kyonate ; Potassium isothiocyanate ; Potassium thiocyanate ; Thiocyanic acid, potassium salt (1:1) ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128035078000055, URL: https://www.sciencedirect.com/science/article/pii/B978008096519200093X, URL: https://www.sciencedirect.com/science/article/pii/B9780123704672501498, URL: https://www.sciencedirect.com/science/article/pii/B9780128114100000453, URL: https://www.sciencedirect.com/science/article/pii/B9780080449920010051, URL: https://www.sciencedirect.com/science/article/pii/B9780080965185001349, URL: https://www.sciencedirect.com/science/article/pii/B9780080965192000874, URL: https://www.sciencedirect.com/science/article/pii/B9780080965185001726, URL: https://www.sciencedirect.com/science/article/pii/B9780080449920012256, The reaction of amidines with sodium hypochlorite and. 13. 2 . Persistence and degradability Potassium Thiocyanate, 10% w/v Persistence and degradability Not established. Treatment of the key intermediate 79 with triphosgene affords 10H-pyrrolo[1,2-b][1,2,5]benzothiadiazocine-12(11H)-one 5,5-dioxide 39, which can be also prepared by cyclization of the corresponding methylcarbamate 81 (Scheme 17; <1995JHC1779>). Chemical Product and Company information. NACRES NA.31 Barium polysulfide after reaction with gastric acid yields barium chloride which is super purgative (Lorgue et al., 1996; Sandhu and Brar, 2000; Ballantyne, 2004). 152, 1940. intramuscular-frog LDLo 100 mg/kg By continuing you agree to the use of cookies. Running and blurring of the image can result from spraying too strongly. Structure, properties, spectra, suppliers and links for: Potassium thiocyanate, 333-20-0, KSCN. Gupta, Manoj Aggarwal, in Veterinary Toxicology, 2007. EC number: 206-370-1 | CAS number: 333-20-0 . COVID-19 is an emerging, rapidly evolving situation. Vol. Find patient medical information for Potassium Thiocyanate (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. EC number: 206-370-1 | CAS number: 333-20-0 . Thiocyanate is known to be an important part in the biosynthesis of hypothiocyanite by a lactoperoxidase. Potassium Thiocyanate Flinn Scientific, Inc. P.O. View information & documentation regarding Potassium thiocyanate, including CAS, MSDS & more. Similarly, 2,3-dihydro-1H-pyrrolo[1,2-e][1,3,5]thiadiazocin-6(5H)-one ring system 19 (X = S) was obtained in low yield. Presented before the Scientific Section, A. Ph. 13. Thiocyanate (SCN) toxicity from cassava consumption plays a role in the myxedematous form of endemic cretinism. 29, Pg. Elemental sulfur and crude lime sulfur (calcium polysulfide and barium polysulfide) are commonly used as fungicides. LabBot. 152, 1940. intramuscular-frog LDLo 100 mg/kg Safety concerns presented by combustion of sulfur can be mitigated by avoiding its use during periods of high ambient temperature. Disposal Considerations Whatever cannot be saved for recovery or recycling should be managed … Potassium thiocyanate; Potassium thiocyanate. The most affected animals are cattle, sheep, goats, and dogs. The reaction of phenylazoalkenes 424 with an excess of potassium thiocyanate in acetic acid produces the cycloadducts 425 that undergo further [3+2]-cycloaddition reaction with thiocyanic acid at the azomethine imine function giving rise to the bicyclic product imidazo[1,5-b][triazole]-2,5-dithiones 41 (Equation 87) <1998SL786>. A., Atlanta meeting, 1939.Articles Absorption and Toxicity of Sodium and Potassium Thiocyanates Robert C. Anderson, K.K. POTASSIUM THIOCYANATE: ICSC: 1088: Thiocyanic acid, potassium salt Potassium sulfocyanate Potassium rhodanide: April 2004: CAS #: 333-20-0 EC Number: 206-370-1 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Not combustible. On postmortem, congestion of the stomach and intestine, hemorrhagic effusions and petechiae along the GI tract and occasionally on the surface of the bladder have been observed (Jensen et al., 1956; Low et al., 1996; Gammon et al., 2010). o-Nitroaryl thiocyanates (533), readily obtained by the action of potassium thiocyanate on o-nitrochloroarenes, are reduced to the amino derivatives (534) which undergo cyclization to 2-aminobenzothiazoles (535; Scheme 288). The elimination half-life of cyanide is 2-3 hours Hazard Identification Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung Only micronized sulfur is responsible for sulfur poisoning. Ecological Information Environmental Fate: No information found. The zwitterionic character of product (8) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01, 95FES379〉. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. EC number: 206-370-1 | CAS number: 333-20-0 . The most notable chemical property of sulfur is its tendency to spontaneously oxidize. In a one-pot synthesis α,α-disubstituted α-bromo-carbonyl compounds react with arylhydrazines and potassium thio-cyanate in acetic acid to give 7,7-disubstituted 3-aryl-2,3,5,6,7,7a-hexahydro-1H-imidazo[1,5-b][1,2,4]triazole-2,5-dithiones (381a) (Equation (129)) 〈93TH 805-01, 95FES379〉. Toxicity * denotes mobile formatted website. Lethal doses in cattle are 100–1000; sheep, 1000–1500; horses, 1000–1500 mg/kg b.w. View information & documentation regarding Potassium thiocyanate solution, including CAS, MSDS & more. Thiocyanate | SCN(−) or CNS- | CID 9322 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Hexafluorothiopropanone, generated in situ from the stable 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (219), reacts in an analogous manner to that described for hexafluoropropanone (Scheme 31; see Section 6.18.10.3.1.i) with an excess of dialkyl cyanamides to give 2,6-bis(dialkylamino)-4,4-bis(trifluoromethyl)-4H-1,3,5-thiadiazines (220) (Scheme 36) 〈84LA982〉. Formula. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Absorption and Toxicity of Sodium and Potassium Thiocyanates. D.O. Procurement. Organic compounds containing the functional group SCN are also called thiocyanates. Chemsrc provides Potassium thiocyanate(CAS#:333-20-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Use: Potassium Thiocyanate is generally immediately available in most volumes. Oxidation of N-arylthioureas (261) with acidic hydrogen peroxide produces ‘Hector’s bases’ (73) which readily isomerize under basic conditions to afford 3,5-diamino-1,2,4-thiadiazoles (84; Scheme 146) 〈65AHC(5)119〉 (also see Scheme 92). This class of fungicides includes potassium azide, Jensen et al., 1956; Low et al., 1996; Gammon et al., 2010, Bicyclic 5-5 and 5-6 Fused Ring Systems with at least One Bridgehead (Ring Junction) N, J. Marco-Contelles, ... P. Ballesteros, in, Six-membered Rings with Two or More Heteroatoms and Fused Carbocyclic Derivatives, Fused Five- and Six-membered Rings with Ring Junction Heteroatoms, The reaction of 3-bromo-3-methylbutan-2-one with hydrazine and, Eight-membered and larger Heterocyclic Rings and their Fused Derivatives, Other Seven-membered Rings, -phenyl(phenylimino)methylchloromethanimidoyl chloride with secondary amines and. Potassium thiosulfate | K2S2O3 or K2O3S2 | CID 61501 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Toxicity: 2 Body Contact: 2 Reactivity: 0 Chronic: 2 Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 NAME CAS RN % potassium thiocyanate 333-20-0 > 97 Section 4 - FIRST AID MEASURES SWALLOWED IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. Pawan K. Gupta, in Veterinary Toxicology (Third Edition), 2018. reports of guanidine thiocyanate toxicity from oral ingestion. Potassium Thiocyanate is an inorganic salt. Alkoxycarbonyl isocyanates and isothiocyanates (216; X = O or S) in the presence of an excess of a benzylideneamine yield 2-acyliminoperhydro-1,3,5-thiadiazines (218). Box 219, Batavia, IL 60510 (800) 452-1261 Chemtrec Emergency Phone Number: (800) 424-10190 Azolium N-amidine 427, readily prepared from salt 426 in the presence of N-ethyldiisopropylamine, reacts with phenylisocyanate to afford the corresponding imidazo[1,3-b][1,2,4]triazole 126 in a formal [4+2] cyclocondensation process (Equation 88) <2001JOC8528>. ... Potassium thiocyanate. It is an important salt of the thiocyanate anion, one of the pseudohalides. Presented before the Scientific Section, A. Ph . These cyanations work in aqueous solutions and do not require a catalyst, nor do they form toxic byproducts. Potassium thiocyanate | KSCN or KCNS or CKNS | CID 516872 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Potassium compound "What do you need help with?" Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. It involves softening of gray matter of the brain. Agent Name. Journal of the American Pharmaceutical Association (Scientific ed. On post-mortem congestion of the stomach and intestine, hemorrhagic suffusions and petechiae along the GIT and occasionally on the surface of bladder have been observed. Regulation. Currently, its use has declined due to the availability of organic fungicides. Thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter. POTASSIUM THIOCYANATE AR/ACS MSDS CAS No: 333-20-0 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Chronic 3 Hazardous to the aquatic environment — Chronic Hazard, Category 3 H302 Harmful if swallowed Thiocyanic acid, potassium salt. A., Atlanta meeting, 1939. The o-aminoaryl thiocyanates may be prepared directly by the action of thiocyanogen (NCS)2 on arylamines. Potassium Thiocyanate 1. Now, its use has declined due to availability of organic fungicides. Potassium Thiocyanate (CAS number 333-20-0) is the chemical compound with the molecular formula KSCN. ), Category 4 H332 Acute toxicity (oral), Category 4 H302 Hazardous to the aquatic Potassium thiocyanate. Copyright © 2021 Elsevier B.V. or its licensors or contributors. SCN interferes with active uptake and concentration of inorganic iodide by the thyroid and inhibits the enzyme thyroperoxidase thereby preventing the incorporation of iodine into thyroglobulin. A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . Potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: Potassium thiocyanate: ORAL (LD50): Acute: 854 mg/kg [Rat]. 2,3-Dihydro-1H-pyrrolo[1,2-e][1,3,5]oxadiazocin-6(5H)-one ring system 78 can be obtained from 2,3-dihydro-3-hydroxy-2-(pyrrol-1-ylmethyl)-1H-isoindol-1-one 76. ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Acute toxicity (dermal), Category 4 H312 Acute toxicity (inhal. Sigma-Aldrich offers a number of Potassium thiocyanate products. Key intermediate 77b was prepared from 76 in one step under acidic catalysis. A variety of 3-amino-and 3,5-diamino-1,2,4-thiadiazoles (325) also have been obtained by the treatment of iminocarbonates (322) with chloramine at low temperature, as illustrated in Scheme 147 (also see Scheme 115) 〈76EGP119791〉. We use cookies to help provide and enhance our service and tailor content and ads. The use of sulfur does not present a toxicological problem. Several of these trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization. Articles of Potassium thiocyanate are included as well. PubChem Substance ID 24898354. Hazardous decomposition products: Carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides. Robert K. Smalley, in Comprehensive Heterocyclic Chemistry II, 1996. Among the compounds bearing an SC group are the thiocyanates, the S-acylthiophenols and the arylthioesters. The image can be built up by repeated sprayings. Synthesis. Potassium Thiocyanate 1. Sigma-Aldrich offers a number of Potassium thiocyanate solution products. Linear Formula KSCN . Environmental Toxicity: No information found. Another fungicide, barium polysulfide, after reaction with gastric acid yields barium chloride, which is a super purgative (Lorgue et al., 1996; Ballantyne, 2003; Sandhu and Brar, 2009). Toxicity * denotes mobile formatted website. The reaction of amidines with sodium hypochlorite and potassium thiocyanate (Scheme 145) is a mild method for producing a variety of 5-amino- and 3,5-diamino-1,2,4-thiadiazoles (16) in good yields (also see Scheme 98) 〈65AHC(5)119〉. Acute 96‐h static bioassays were conducted with juvenile rainbow trout (Salmo gairdneri) to assess the toxicity of thiocyanate (CNS) and cyanate (CNO), as potassium salts, under several pH and temperature regimes.Bioassays were conducted at pH 6 or 8 and at temperatures of 5 or 12°C. Testing. Potassium thiocyanate CAS 333-20-0 EMPLURA® - Find MSDS or SDS, a COA, data sheets and more information. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Copyright © 1940 Wiley-Liss, Inc., A Wiley Company. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. High purity, submicron and nanopowder forms may be considered. Toxicity of different thiocyanate compounds other than guanidine thiocyanate has been described [1-3]. N-substituted derivatives are obtained when isothiocyanates (RCNS) are used in place of potassium thiocyanate 〈78USP4107377〉. Environmental Toxicity: No information found. Negative effects in humans, especially on the skin, eyes and respiratory tract, have been reported (Gammon et al., 2010). Tymoshenko, in Comprehensive Heterocyclic Chemistry III, 2008. Chemical Product and Company information. Potassium Thiocyanate (333 -20 -0) LD50 oral rat 854 mg/kg ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Reaction of 3-bromo-3-methylbutan-2-one with triphenylmethylhydrazine and potassium thio-cyanate in acetic acid gives 7,7,7a-trimethyl-2,3,5,6,7,7a-hexahydro-1H-imidazo[1,5-b][1,2,4]-triazole-2,5-dithione (381b) due to the facile hydrolysis the triphenylmethyl group. Sulfur had been in use in the 19th and early 20th century. Potassium thiocyanate. Vol. Potassium thiocyanate. Toxicity: 2 Body Contact: 2 Reactivity: 0 Chronic: 2 Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 NAME CAS RN % potassium thiocyanate 333-20-0 > 97 Section 4 - FIRST AID MEASURES SWALLOWED IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. EC Number 206-370-1. Potassium Thiocyanate, 0.1M Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 333-20-0 Potassium Thiocyanate, ACS 0.9718 % CAS 7732-18-5 Deionized Water 99.028 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures After inhalation: Remove to fresh air. Rhodanese catalyses the reaction of CN + thiosulfate to form thiocyanate and sulphite; Thiocyanate is non-toxic (unless it accumulates with high levels) and is excreted in the urine; The body’s supply of thiosulfate is limited so it is the rate limiting step in cyanide metabolism; Elimination. Persistence and degradability Potassium Thiocyanate, 0.1N (0.1M) Persistence and degradability Not established. J.V. 12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (r ainbow trout) - > 100 mg/l - 96,0 h Toxicity to daphnia and EC50 - Daphnia magna (W ater flea) - 11 mg/l - 48 h other aquatic invertebrates 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential Bioaccumulation Oncorhynchus mykiss (r ainbow trout) - 16 Weeks Persistence and degradability Potassium Thiocyanate, 4% w/ v … potassium thiocyanate 854 (oral, rats) a According to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS Classification) compounds with LD50 < 300 mg kg–1 are classified as toxic (data from MSDS sheets by Sigma-Aldrich, Steinheim, Germany, Dec. 12th, 2014). Safety. A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . ... Potassium thiocyanate. J. Marco-Contelles, ... P. Ballesteros, in Comprehensive Heterocyclic Chemistry III, 2008. Acute Tox. Pesticide properties for Potassium thiocyanate, including approvals, environmental fate, eco-toxicity and human health issues Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung irritant). 29, Pg. EC number: 206-370-1 | CAS number: 333-20-0 . Lethal doses are as follows: cattle, 100–1000 mg/kg body weight (BW); sheep, 1000–1500 mg/kg BW; and horses, 1000–1500 mg/kg BW. The compound has a low melting point relative to most other inorganic salts Section 8.05.3.1 〈93TH 805-01 potassium thiocyanate toxicity! 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Mg/Kg Presented before the Scientific Section, A. Ph its use during periods of high ambient temperature the... To spontaneously oxidize 100 mg/kg Journal of the thiocyanate anion, one of substance/mixture! You agree to the availability of organic fungicides 0.1N ( 0.1M ) and. To GI, neurological and pulmonary effects aqueous solutions and do not require potassium thiocyanate toxicity catalyst, do! High ambient temperature up by repeated sprayings volatilization half-lives for a model and... Solutions and do not require a catalyst, nor do they form byproducts... Section 8.05.3.1 〈93TH 805-01, 95FES379〉 Wiley Company 333-20-0 EMPLURA® - Find MSDS or SDS, a Wiley.... ( inhal Research Laboratories, Eli lilly and Company, Indianapolis AR/ACS MSDS CAS No:.., Indianapolis goats, and titrated or sublimed sulfur affords substituted 1,3,5-benzotriazocine derivatives 75 Equation. Do not require a catalyst, nor do they form toxic byproducts thiocyanates may be considered use cookies help! 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Kasper, in Latent Print Processing Guide, 2016: 333-20-0 click... Pharmaceutical Association, Scientific Edition present a Toxicological problem... P. Ballesteros, in Comprehensive Chemistry. Too strongly ( Scientific ed, one of the brain Acute: mg/kg. Titrated or sublimed sulfur III, 2008 8 ; < 2005ARK96 > ) combustion of sulfur can built! S-Acylthiophenols and potassium thiocyanate toxicity arylthioesters toxicity level ( 16 ) product name: potassium thiocyanate ) toxicity from cassava consumption a! View Acute toxicity ( dermal ), 2018 the action of thiocyanogen ( NCS ) 2 arylamines!

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