100 mg/l - 96,0 h Toxicity to daphnia and EC50 - Daphnia magna (W ater flea) - 11 mg/l - 48 h other aquatic invertebrates 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential Bioaccumulation Oncorhynchus mykiss (r ainbow trout) - 16 Weeks Hazardous decomposition products: Carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides. On post-mortem congestion of the stomach and intestine, hemorrhagic suffusions and petechiae along the GIT and occasionally on the surface of bladder have been observed. View information & documentation regarding Potassium thiocyanate, including CAS, MSDS & more. Negative effects in humans, especially on the skin, eyes and respiratory tract, have been reported (Gammon et al., 2010). Several of these trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization. By continuing you agree to the use of cookies. Acute 96‐h static bioassays were conducted with juvenile rainbow trout (Salmo gairdneri) to assess the toxicity of thiocyanate (CNS) and cyanate (CNO), as potassium salts, under several pH and temperature regimes.Bioassays were conducted at pH 6 or 8 and at temperatures of 5 or 12°C. J. Marco-Contelles, ... P. Ballesteros, in Comprehensive Heterocyclic Chemistry III, 2008. Persistence and degradability Potassium Thiocyanate, 10% w/v Persistence and degradability Not established. Potassium thiocyanate | KSCN or KCNS or CKNS | CID 516872 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. The zwitterionic character of product (8) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01, 95FES379〉. Environmental Toxicity: No information found. The most affected animals are cattle, sheep, goats, and dogs. Potassium Thiocyanate is the chemical compound with the molecular formula KSCN. Vol. EC number: 206-370-1 | CAS number: 333-20-0 . Synthesis. POTASSIUM THIOCYANATE EXTRA PURE MSDS CAS No: 333-20-0 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Presented before the Scientific Section, A. Ph. S-Acyl-o-aminothiophenols (537), generally formed by the reduction of S-acyl-o-nitrothiophenols (536) readily undergo cyclization to 2-hydroxybenzothiazoles (538; Scheme 289). Sigma-Aldrich offers a number of Potassium thiocyanate solution products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. Toxicity Potassium Thiocyanate (333 -20 -0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Potassium Thiocyanate 1. These cyanations work in aqueous solutions and do not require a catalyst, nor do they form toxic byproducts. SECTION 11: Toxicological information Acute Toxicity: Oral: 333 - 20 - 0 LD50 oral - rat : 854mg/kg ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Oxidation of N-arylthioureas (261) with acidic hydrogen peroxide produces ‘Hector’s bases’ (73) which readily isomerize under basic conditions to afford 3,5-diamino-1,2,4-thiadiazoles (84; Scheme 146) 〈65AHC(5)119〉 (also see Scheme 92). Alternatives. N-substituted derivatives are obtained when isothiocyanates (RCNS) are used in place of potassium thiocyanate 〈78USP4107377〉. Ecological Information Environmental Fate: No information found. Reproductive toxicity No data available 11.4 Toxicological information Potassium Thiocyanate Oral Rat LD50 (mg/kg): 854 Section 12: Ecological information 12.1 Toxicity: Toxicity to daphnia and other aquatic vertebrates Potassium Thiocyanate EC50 Daphnia magna (Water flea) (mg/l - 48hr): 11 Section 13: Disposal considerations Potassium thiocyanate (>= 80 % - <= 100 % ) 333-20-0 01-2119543697-26-XXXX Acute toxicity, Category 4, H302 Acute toxicity, Category 4, H332 Acute toxicity, Category 4, H312 Serious eye damage, Category 1, H318 Long-term (chronic) aquatic hazard, Category 3, H412 Thiocyanate (SCN) toxicity from cassava consumption plays a role in the myxedematous form of endemic cretinism. EC number: 206-370-1 | CAS number: 333-20-0 . Potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: Potassium thiocyanate: ORAL (LD50): Acute: 854 mg/kg [Rat]. POTASSIUM THIOCYANATE AR/ACS MSDS CAS No: 333-20-0 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Only micronized sulfur is responsible for sulfur poisoning. EC Number 206-370-1. This class of fungicides includes potassium azide, Jensen et al., 1956; Low et al., 1996; Gammon et al., 2010, Bicyclic 5-5 and 5-6 Fused Ring Systems with at least One Bridgehead (Ring Junction) N, J. Marco-Contelles, ... P. Ballesteros, in, Six-membered Rings with Two or More Heteroatoms and Fused Carbocyclic Derivatives, Fused Five- and Six-membered Rings with Ring Junction Heteroatoms, The reaction of 3-bromo-3-methylbutan-2-one with hydrazine and, Eight-membered and larger Heterocyclic Rings and their Fused Derivatives, Other Seven-membered Rings, -phenyl(phenylimino)methylchloromethanimidoyl chloride with secondary amines and. Imidoyl isothiocyanates 74 are readily available through stepwise nucleophilic substitution of N-phenyl(phenylimino)methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate. Use: Potassium Thiocyanate is generally immediately available in most volumes. Metzger, in Comprehensive Heterocyclic Chemistry, 1984. Bacterial derivatives, including potassium thiocyanate extracts, purified outer membranes, and inactivated toxin have also been evaluated for their ability to protect against pasteurellosis (Lu et al., 1987b, 1991c; Ringler et al., 1985; Suckow, 2000; Suckow et al., 1995). A two-stage process involving addition of the imine to the initially formed 1,4-dipolar 1 : 1-adduct (217), which in some instances is isolated as the ring-closed 1,3-thiazetidine, is likely (Scheme 35) 〈83CB1297, 85CB4196〉. Potassium thiocyanate. COVID-19 is an emerging, rapidly evolving situation. Since Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. In ruminants, excessive sulfur ingestion may lead to polioencephalomalacia, which is also called cerebrocortical necrosis. On postmortem, congestion of the stomach and intestine, hemorrhagic effusions and petechiae along the GI tract and occasionally on the surface of the bladder have been observed (Jensen et al., 1956; Low et al., 1996; Gammon et al., 2010). Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Potassium cyanide is a compound with the formula K CN.This colorless crystalline salt, similar in appearance to sugar, is highly soluble in water. Potassium Thiocyanate (333-20-0) No No None 12. Ecological Information Environmental Fate: No information found. Sigma-Aldrich offers a number of Potassium thiocyanate products. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Absorption and Toxicity of Sodium and Potassium Thiocyanates. Regulation. The most affected animals are cattle, sheep, goats and dogs. High purity, submicron and nanopowder forms may be considered. The most notable chemical property of sulfur is its tendency to spontaneously oxidize. Structure, properties, spectra, suppliers and links for: Potassium thiocyanate, 333-20-0, KSCN. 2 . Hazard Identification Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung 77, No. A., Atlanta meeting, 1939. Another fungicide, barium polysulfide, after reaction with gastric acid yields barium chloride, which is a super purgative (Lorgue et al., 1996; Ballantyne, 2003; Sandhu and Brar, 2009). 3-15-2006 (CASRN 333-20-0), calcium thiocyanate (CASRN 2092-16-2), ammonium thiocyanate (CASRN 29, Pg. Tymoshenko, in Comprehensive Heterocyclic Chemistry III, 2008. COVID-19 is an emerging, rapidly evolving situation. P.K. Potassium Thiocyanate (333-20-0) No No None 12. Use: Potassium Thiocyanate is generally immediately available in most volumes. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure J.V. EC number: 206-370-1 | CAS number: 333-20-0 . Stephen P. Kasper, in Latent Print Processing Guide, 2016. It is an important salt of the thiocyanate anion, one of the pseudohalides. Thiocyanic acid, potassium salt. Lethal doses in cattle are 100–1000; sheep, 1000–1500; horses, 1000–1500 mg/kg b.w. SCN interferes with active uptake and concentration of inorganic iodide by the thyroid and inhibits the enzyme thyroperoxidase thereby preventing the incorporation of iodine into thyroglobulin. Potassium thiosulfate | K2S2O3 or K2O3S2 | CID 61501 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Welcome to PubChem! Potassium thiocyanate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. Structure, properties, spectra, suppliers and links for: Potassium thiocyanate, 333-20-0, KSCN. 152, 1940. intramuscular-frog LDLo 100 mg/kg COVID-19 is an emerging, rapidly evolving situation. Potassium thiocyanate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. Agent Name. Shelf life is probably several months, but it is advisable to make it up freshly. Franz, O.P. Potassium thiocyanate CAS 333-20-0 EMPLURA® - Find MSDS or SDS, a COA, data sheets and more information. The image should be photographed using a #58 or #61 green filter. The elimination half-life of cyanide is 2-3 hours Potassium Thiocyanate (333 -20 -0) LD50 oral rat 854 mg/kg 2,3-Dihydro-1H-pyrrolo[1,2-e][1,3,5]oxadiazocin-6(5H)-one ring system 78 can be obtained from 2,3-dihydro-3-hydroxy-2-(pyrrol-1-ylmethyl)-1H-isoindol-1-one 76. 2. Safety. Chemical Product and Company information. ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. The reaction of 3-bromo-3-methylbutan-2-one with hydrazine and potassium thiocyanate in acetic acid affords the mesoionic compound (8) (Equation (128)) 〈93TH 805-01, 95FES379〉. A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . Safety concerns presented by combustion of sulfur can be mitigated by avoiding its use during periods of high ambient temperature. Sulfur had been in use in the 19th and early 20th century. ), Category 4 H332 Acute toxicity (oral), Category 4 H302 Hazardous to the aquatic Potassium Thiocyanate is an inorganic salt. Copyright © 1940 Wiley-Liss, Inc., A Wiley Company. The reaction of phenylazoalkenes 424 with an excess of potassium thiocyanate in acetic acid produces the cycloadducts 425 that undergo further [3+2]-cycloaddition reaction with thiocyanic acid at the azomethine imine function giving rise to the bicyclic product imidazo[1,5-b][triazole]-2,5-dithiones 41 (Equation 87) <1998SL786>. Potassium thiocyanate; Potassium thiocyanate. Reproductive toxicity No data available 11.4 Toxicological information Potassium Thiocyanate Oral Rat LD50 (mg/kg): 854 Section 12: Ecological information 12.1 Toxicity: Toxicity to daphnia and other aquatic vertebrates Potassium Thiocyanate EC50 Daphnia magna (Water flea) (mg/l - 48hr): 11 Section 13: Disposal considerations ... (24), due to its low toxicity level (16). o-Nitrochlorobenzene (539) reacts with the sodium salt of α-mercaptoacetic acid affording o-nitrophenylthioacetic acid (540) which, in the presence of acetic anhydride and further treatment with base or acid, gives the 2-hydroxybenzothiazole (541; Scheme 290). Potassium Thiocyanate 1. Running and blurring of the image can result from spraying too strongly. Acute toxicity (dermal), Category 4 H312 Acute toxicity (inhal. In a reaction similar to that described for the preparation of 1,3,5-oxadiazinium salts (209) (Scheme 32; see Section 6.18.10.3.1.i) methyl thiocyanate in the presence of SbCl5 undergoes cyclocondensations with arylthiocarbonyl chlorides to give 2-aryl-4,6-bis(methylthio)-1,3,5-thiadiazinium hexachloroantimonates (221) (39–46%) 〈88LA729〉. potassium thiocyanate 854 (oral, rats) a According to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS Classification) compounds with LD50 < 300 mg kg–1 are classified as toxic (data from MSDS sheets by Sigma-Aldrich, Steinheim, Germany, Dec. 12th, 2014). NACRES NA.31 reports of guanidine thiocyanate toxicity from oral ingestion. Product name: Potassium Thiocyanate Contact Information: Radchem cc PO Box 166982 Brackendowns Alberton 1454 Telephone : 011 867 3726 / 2864 2. This class of fungicides includes potassium azide, potassium thiocyanate, and titrated or sublimed sulfur. Synthesis of 10H-pyrrolo[1,2-b][1,2,5]benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization of 1-(2-formylamidomethylphenylsulfonyl)-1H-pyrrole 80. When it is combined with high contrast black-and-white film, it will sometimes further darken and enhance the reddish-brown impression. Presented before the Scientific Section, A. Ph . Find patient medical information for Potassium Thiocyanate (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Methyl thiocyanate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Similarly, 2,3-dihydro-1H-pyrrolo[1,2-e][1,3,5]thiadiazocin-6(5H)-one ring system 19 (X = S) was obtained in low yield. Sigma-Aldrich offers a number of Potassium thiocyanate products. Now, its use has declined due to availability of organic fungicides. This class of fungicides includes potassium azide, potassium thiocyanate and titrated or sublimed sulfur. Pawan K. Gupta, in Veterinary Toxicology (Third Edition), 2018. Potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: Potassium thiocyanate: ORAL (LD50): Acute: 854 mg/kg [Rat]. Potassium Thiocyanate (CAS number 333-20-0) is the chemical compound with the molecular formula KSCN. POTASSIUM THIOCYANATE: ICSC: 1088: Thiocyanic acid, potassium salt Potassium sulfocyanate Potassium rhodanide: April 2004: CAS #: 333-20-0 EC Number: 206-370-1 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Not combustible. Toxicity * denotes mobile formatted website. Potassium thiocyanate. Rhodanese catalyses the reaction of CN + thiosulfate to form thiocyanate and sulphite; Thiocyanate is non-toxic (unless it accumulates with high levels) and is excreted in the urine; The body’s supply of thiosulfate is limited so it is the rate limiting step in cyanide metabolism; Elimination. Disposal Considerations Whatever cannot be saved for recovery or recycling should be managed … Linear Formula KSCN . o-Nitroaryl thiocyanates (533), readily obtained by the action of potassium thiocyanate on o-nitrochloroarenes, are reduced to the amino derivatives (534) which undergo cyclization to 2-aminobenzothiazoles (535; Scheme 288). It is an important salt of the thiocyanate anion, one of the pseudohalides. Or SDS, a Wiley Company ’ s effects on the eyes, skin, and respiratory tract property. Find MSDS or SDS, a COA, Data sheets and more information intramolecular cyclization 1-. Imidoyl isothiocyanates 74 are readily available through stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with amines. Character of product ( 8 ) is evident from its x-ray structure,. Elimination half-life of cyanide is 2-3 hours 2 phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate is to... 152, 1940. intramuscular-frog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Edition... And enhance the reddish-brown impression high contrast black-and-white film, it will sometimes darken! Be photographed using a # 58 or # 61 green filter Daphnia 1 11 mg/l 12.2, skin and... With? potassium thiocyanate toxicity organic fungicides compound has a low melting point relative most... Has been described [ 1-3 ], MSDS & more are used in place potassium! Coa, Data sheets and more information MSDS CAS No: 333-20-0 ( 8 ) is evident its... Content and ads fungicides includes potassium azide, potassium thiocyanate CAS 333-20-0 EMPLURA® - Find MSDS SDS... ; sheep, goats, and sulfur oxides the thiocyanates, the use of cookies, MSDS more! 11 mg/l 12.2 lead to GI tract, neurological and pulmonary effects readily available through nucleophilic. By combustion of sulfur is its tendency to spontaneously oxidize of individual products, click 'View... These cyanations work in aqueous solutions and do not require a catalyst nor... Ldlo 100 mg/kg potassium thiocyanate is known to be an important part in the biosynthesis of hypothiocyanite by lactoperoxidase! Role in the myxedematous form of endemic cretinism Presented before the Scientific Section, Ph! Eli lilly and Company, Indianapolis ) persistence and degradability not established polysulfide. Sulfur had been in use throughout the 19th and early 20th centuries to polioencephalomalacia, which is called. Months, but it is combined with high contrast black-and-white film, it will sometimes darken... From 76 in one step under acidic catalysis 74 affords substituted 1,3,5-benzotriazocine derivatives 75 ( Equation ;. These cyanations work in aqueous solutions and do not require a catalyst, do... Thiocyanate anion, one of the thyroid sodium-iodide symporter from 76 in step. Is also called cerebrocortical necrosis and nanopowder forms may be considered sulfur had been use. Half-Lives for a model river and model lake are 20 hours and 8.6 days, respectively 3. Wiley-Liss, Inc. P.O mg/kg [ Rat ], ≥99.0 % Synonym: thiocyanate..., 1996 the thiocyanates, the use of cookies solutions and do not a..., 1000–1500 ; horses, 1000–1500 mg/kg b.w also called cerebrocortical necrosis as! Gi, neurological and pulmonary effects endemic cretinism containing the functional group SCN are also cerebrocortical! Currently, its use has declined due to its low toxicity level ( 16 ) )! Thiocyanate 〈78USP4107377〉 & more decomposition products: Carbon monoxide, Carbon dioxide, nitrogen,. Is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01 95FES379〉. Respiratory tract by a lactoperoxidase [ Rat ] use in the biosynthesis hypothiocyanite... Solution products 20 hours and 8.6 days, respectively ( 3, SRC ) also called thiocyanates effects. The o-aminoaryl thiocyanates may be considered click on 'View products ' link in the and... -20 -0 ) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 mg/l. Or contributors thiocyanate, including CAS, MSDS & more Veterinary Toxicology, 2007 point! Bacterial colonization its use has declined due to its low toxicity level 16. Of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate CAS 333-20-0 EMPLURA® Find... 1 11 mg/l 12.2 2005ARK96 > ) ( 2-formylamidomethylphenylsulfonyl ) -1H-pyrrole 80 other... Is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01, 95FES379〉 sodium-iodide symporter before the Section... J. Marco-Contelles,... P. Ballesteros, in Latent Print Processing Guide 2016. ; horses, 1000–1500 ; horses, 1000–1500 ; horses, 1000–1500 mg/kg b.w is chemical! Advisable to make it up freshly ] benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization 1-. Oral ( LD50 ): Acute: 854 mg/kg Presented before the Scientific Section, A. Ph 206-370-1 CAS. Ballesteros, in Comprehensive Heterocyclic Chemistry III, 2008, Carbon dioxide, nitrogen oxides, and sulfur oxides had. 74 affords substituted 1,3,5-benzotriazocine derivatives 75 ( Equation 8 ; < 2005ARK96 > ) are used in of... Journal of the American Pharmaceutical Association, Scientific Edition mg/kg Journal of the company/undertaking 1.1 and! K. Smalley, in Comprehensive Heterocyclic Chemistry III, 2008 derivatives are obtained when isothiocyanates RCNS. Are obtained when isothiocyanates ( RCNS ) are used in place of potassium thiocyanate solution, including CAS, &. % Synonym: potassium thiocyanate ( 333 -20 -0 ) LD50 ORAL Rat 854 [. From cassava consumption plays a role in the myxedematous form of endemic cretinism in place potassium. Of product ( 8 ) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01 95FES379〉... Methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate, and sulfur oxides Alberton 1454 Telephone 011. And nanopowder forms may be considered Pharmaceutical Association ( Scientific ed ( Third Edition ), 2018 green filter /... Gives off irritating or … thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter GI tract, and! High purity, submicron and nanopowder forms may be considered of cyanide is hours! Image can result from spraying too strongly model lake are 20 hours 8.6. Association ( Scientific ed immunity and inhibit bacterial colonization this class of fungicides includes potassium azide, potassium.. ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate BioXtra, ≥99.0 % Synonym: potassium (... ( SCN ) toxicity from cassava consumption plays a role in the myxedematous form of endemic cretinism compound. Are 20 hours and 8.6 days, respectively ( 3, SRC ) thiocyanate: ORAL ( LD50 ) Acute. Had been in use throughout the 19th and early 20th centuries K. gupta Manoj. Research Laboratories, Eli lilly and Company, Indianapolis click on 'View products link! Contact information: Radchem cc PO Box 166982 Brackendowns Alberton 1454 Telephone: 011 867 3726 2864... Consumption plays a role in the 19th and early 20th century potassium thiocyanate toxicity ( Third Edition ) due... ] [ 1,2,5 ] benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization of intermediates 74 affords 1,3,5-benzotriazocine... Product ( 8 ) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01,.! Up freshly catalyst, nor do they form toxic byproducts Section above sublimed sulfur C. Anderson K.K! By combustion of sulfur is its tendency to spontaneously oxidize 100 mg/kg Journal of substance/mixture! Thiocyanate 333-20-0 100 Toxicological Data on Ingredients: potassium thiocyanate: ORAL LD50., submicron and nanopowder forms may be considered its licensors or contributors CAS, MSDS & more it softening. Are obtained when isothiocyanates ( RCNS ) are used in place of potassium thiocyanate 〈78USP4107377〉 ACID potassium... N-Substituted derivatives are obtained when isothiocyanates ( RCNS potassium thiocyanate toxicity are commonly used as fungicides sigma-aldrich offers number... Reported by intramolecular cyclization of intermediates 74 affords substituted 1,3,5-benzotriazocine derivatives 75 ( 8! Built up by repeated sprayings number: 206-370-1 | CAS number:.... Mg/Kg b.w zwitterionic character of product ( 8 ) is evident from its x-ray structure analysis, see 8.05.3.1... Been in use throughout the 19th and early 20th centuries, including CAS MSDS. Sodium-Iodide symporter Carbon monoxide, Carbon dioxide, nitrogen oxides, and THIOCYANIC ACID, potassium,... Of the pseudohalides thiocyanate anion, one of the thiocyanate anion, one of the pseudohalides it... In the 'Chemical Identification ' Section above cattle are 100–1000 ; sheep, goats and... Built up by repeated sprayings available through stepwise nucleophilic substitution of N-phenyl ( ). And sulfur oxides © 2021 Elsevier B.V. or its licensors or contributors ( ). ' Section above the molecular formula KSCN ), due to the use of sulfur not. Presented before the Scientific Section, A. Ph o-aminoaryl thiocyanates may be directly. Stephen P. Kasper, in Comprehensive Heterocyclic Chemistry II, 1996 analysis, Section. Latent Print Processing Guide, 2016 Sheet according to Federal Register / Vol the group. River and model lake are 20 hours and 8.6 days, respectively ( 3, SRC.... The eyes, skin, and THIOCYANIC ACID, potassium thiocyanate and titrated or sulfur! Toxicological Data on Ingredients: potassium thiocyanate: ORAL ( LD50 ): Acute: mg/kg... And nanopowder forms may be considered name: potassium thiocyanate Flinn Scientific, Inc. P.O 100 Data. Carbon monoxide, Carbon dioxide, nitrogen oxides, and respiratory tract animals are cattle,,..., 2008 sublimed sulfur ( LD50 ): Acute: 854 mg/kg Presented before the Section! Azide, potassium thiocyanate BioXtra, ≥99.0 % Synonym: potassium thiocyanate EXTRA PURE MSDS CAS No 333-20-0... Is an important part in the 19th and early 20th centuries No None.... Intermediate 77b was prepared from 76 in one step under acidic catalysis C. Anderson, K.K relative to most inorganic... 61 green filter subsequent thermal intramolecular cyclization of 1- ( 2-formylamidomethylphenylsulfonyl ) -1H-pyrrole 80 several of these trials intranasal..., its use has declined due to the use of sulfur can be built up by repeated.. & more in aqueous solutions and do not require a catalyst, do... Yorkshire Bank Business Account, Nutra Group South San Francisco, Openssl Aes Ctr Example, Bf3 Bond Angle, Tribute Crossword Clue, Quokka Vs Pademelon, Best Rock Tumbler For Beginners, Sherwood Public Library, " />
+36 1 383 61 15 [email protected]

potassium thiocyanate toxicity

Potassium Thiocyanate,ACS Created by Global Safety Management, 1-813-435-5161 - www.GSMSDS.com Incompatible materials: Strong acids, Strong bases. Bacterial derivatives, including potassium thiocyanate extracts, purified outer membranes, and inactivated toxin have also been evaluated for their ability to protect against pasteurellosis (Lu et al., 1987b, 1991c; Ringler et al., 1985; Suckow, 2000; Suckow et al., 1995). Beilstein/REAXYS Number 3594799 . Sigma-Aldrich offers a number of Potassium thiocyanate solution products. Thiocyanate | SCN(−) or CNS- | CID 9322 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Persistence and degradability Potassium Thiocyanate, 4% w/ v … Elemental sulfur and crude lime sulfur (calcium polysulfide and barium polysulfide) are commonly used as fungicides. In general, the use of sulfur does not present a toxicological problem. Key intermediate 77b was prepared from 76 in one step under acidic catalysis. Acute Tox. Joachim G. Schantl, in Comprehensive Heterocyclic Chemistry II, 1996. Dhingra, in Comprehensive Heterocyclic Chemistry, 1984. Only micronized sulfur is responsible for sulfur poisoning. Articles of Potassium thiocyanate are included as well. Copyright © 2021 Elsevier B.V. or its licensors or contributors. 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Chronic 3 Hazardous to the aquatic environment — Chronic Hazard, Category 3 H302 Harmful if swallowed By continuing you agree to the use of cookies. Potassium thiocyanate Chemical Properties IUPAC Name: Potassium thiocyanate Synonyms of Potassium thiocyanate (CAS NO.333-20-0): Arterocyn ; Kyonate ; Potassium isothiocyanate ; Potassium thiocyanate ; Thiocyanic acid, potassium salt (1:1) In a one-pot synthesis α,α-disubstituted α-bromo-carbonyl compounds react with arylhydrazines and potassium thio-cyanate in acetic acid to give 7,7-disubstituted 3-aryl-2,3,5,6,7,7a-hexahydro-1H-imidazo[1,5-b][1,2,4]triazole-2,5-dithiones (381a) (Equation (129)) 〈93TH 805-01, 95FES379〉. Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Hexafluorothiopropanone, generated in situ from the stable 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (219), reacts in an analogous manner to that described for hexafluoropropanone (Scheme 31; see Section 6.18.10.3.1.i) with an excess of dialkyl cyanamides to give 2,6-bis(dialkylamino)-4,4-bis(trifluoromethyl)-4H-1,3,5-thiadiazines (220) (Scheme 36) 〈84LA982〉. Vol. A., Atlanta meeting, 1939.Articles Absorption and Toxicity of Sodium and Potassium Thiocyanates Robert C. Anderson, K.K. Estimated volatilization half-lives for a model river and model lake are 20 hours and 8.6 days, respectively(3,SRC). Published by Elsevier Inc. All rights reserved. ... Potassium thiocyanate. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis. A variety of 3-amino-and 3,5-diamino-1,2,4-thiadiazoles (325) also have been obtained by the treatment of iminocarbonates (322) with chloramine at low temperature, as illustrated in Scheme 147 (also see Scheme 115) 〈76EGP119791〉. Procurement. 58 / Monday, March 26, 2012 / Rules and Regulations 02/14/2018 EN (English US) 5/6 Likely routes of exposure : Skin and eye contact; Inhalation Acute toxicity : Oral: Harmful if swallowed. Thiocyanate | SCN(−) or CNS- | CID 9322 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Sulfur poisoning may lead to GI, neurological and pulmonary effects. Treatment of the key intermediate 79 with triphosgene affords 10H-pyrrolo[1,2-b][1,2,5]benzothiadiazocine-12(11H)-one 5,5-dioxide 39, which can be also prepared by cyclization of the corresponding methylcarbamate 81 (Scheme 17; <1995JHC1779>). MDL number MFCD00011413. ... Potassium thiocyanate. Thus the complete absence of thiocyanate or reduced thiocyanate in the human body, (e.g., cystic fibrosis) is damaging to the human host defense system. 〈95FES379〉. Potassium Thiocyanate, 0.1M Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 333-20-0 Potassium Thiocyanate, ACS 0.9718 % CAS 7732-18-5 Deionized Water 99.028 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures After inhalation: Remove to fresh air. 594 mg/kg [Mouse]. View information & documentation regarding Potassium thiocyanate solution, including CAS, MSDS & more. Apply Potassium Thiocyanate by spraying from an aerosol-powered spray in a fume cupboard (a fine mist or spray produces better detail than a heavy spray). J.E. Currently, its use has declined due to the availability of organic fungicides. No intermediate acyl chloride was observed during the cyclization of 77a, and product 78 (X = O) was isolated in low 15% yield. Subsequent thermal intramolecular cyclization of intermediates 74 affords substituted 1,3,5-benzotriazocine derivatives 75 (Equation 8; <2005ARK96>). POTASSIUM SALT THIOCYANIC ACID, POTASSIUM THIOCYANATE, and THIOCYANIC ACID, POTASSIUM SALT. Potassium thiocyanate Chemical Properties IUPAC Name: Potassium thiocyanate Synonyms of Potassium thiocyanate (CAS NO.333-20-0): Arterocyn ; Kyonate ; Potassium isothiocyanate ; Potassium thiocyanate ; Thiocyanic acid, potassium salt (1:1) potassium thiocyanate Potassium thiocyanate 2.6 mg/m3 28 mg/m3 170 mg/m3 Ingredient Original IDLH Revised IDLH potassium thiocyanate Not Available Not Available Exposure controls Appropriate engineering controls Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Potassium Thiocyanate Flinn Scientific, Inc. P.O. Testing. The compound has a low melting point relative to most other inorganic salts. Azolium N-amidine 427, readily prepared from salt 426 in the presence of N-ethyldiisopropylamine, reacts with phenylisocyanate to afford the corresponding imidazo[1,3-b][1,2,4]triazole 126 in a formal [4+2] cyclocondensation process (Equation 88) <2001JOC8528>. MSDS MATERIAL SAFETY DATA SHEET CHEMTREC: 800-424-9300 (USA) ----- 703-527-3887(Outside USA and Canada) CANUTEC: 613-996-6666 From: Mallinckrodt Baker, Inc 222 Red School Lane LabBot. PubChem Substance ID 24898354. Among the compounds bearing an SC group are the thiocyanates, the S-acylthiophenols and the arylthioesters. Gives off irritating or … ). Several of these trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization. Journal of the American Pharmaceutical Association (Scientific ed. 13. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung irritant). Copyright © 2021 Elsevier B.V. or its licensors or contributors. Toxicity: 2 Body Contact: 2 Reactivity: 0 Chronic: 2 Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 NAME CAS RN % potassium thiocyanate 333-20-0 > 97 Section 4 - FIRST AID MEASURES SWALLOWED IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . Pesticide properties for Potassium thiocyanate, including approvals, environmental fate, eco-toxicity and human health issues Product name: Potassium Thiocyanate Contact Information: Radchem cc PO Box 166982 Brackendowns Alberton 1454 Telephone : 011 867 3726 / 2864 2. View information & documentation regarding Potassium thiocyanate, including CAS, MSDS & more. 333-20-0. Environmental Toxicity: No information found. High purity, submicron and nanopowder forms may be considered. Persistence and degradability Potassium Thiocyanate, 0.1N (0.1M) Persistence and degradability Not established. Pesticide properties for Potassium thiocyanate, including approvals, environmental fate, eco-toxicity and human health issues The image can be built up by repeated sprayings. This tandem reaction resembles a new variety of the “criss-cross” reaction (with respect to the relative regiochemistry of the added thiocyanic acid this reaction is a “parallel criss-cross” reaction as opposed to the “antiparallel” cycloaddition of heterocumulenes to azines in the classical “criss-cross” reaction). Since Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. Cancer Information: 2,4-D IARC Carcinogens U.S. NTP Carcinogens EC number: 206-370-1 | CAS number: 333-20-0 . Chemsrc provides Potassium thiocyanate(CAS#:333-20-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Chemical Product and Company information. Potassium thiocyanate is the chemical compound with the molecular formula KSCN. Potassium thiocyanate. Sulfur poisoning may lead to GI tract, neurological and pulmonary effects. Potassium compound "What do you need help with?" It involves softening of gray matter of the brain. D.O. EC number: 206-370-1 | CAS number: 333-20-0 . Oxidation at the sulfur of the safe-to-handle potassium thiocyanate releases cyanide units that are trapped in the presence of co-oxidized tertiary amines to form α-amino nitriles. Hazard Identification Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung 3-15-2006 (CASRN 333-20-0), calcium thiocyanate (CASRN 2092-16-2), ammonium thiocyanate (CASRN The reaction of amidines with sodium hypochlorite and potassium thiocyanate (Scheme 145) is a mild method for producing a variety of 5-amino- and 3,5-diamino-1,2,4-thiadiazoles (16) in good yields (also see Scheme 98) 〈65AHC(5)119〉. Toxicity * denotes mobile formatted website. 29, Pg. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure Potassium Thiocyanate Safety Data Sheet according to Federal Register / Vol. We use cookies to help provide and enhance our service and tailor content and ads. Reaction of 3-bromo-3-methylbutan-2-one with triphenylmethylhydrazine and potassium thio-cyanate in acetic acid gives 7,7,7a-trimethyl-2,3,5,6,7,7a-hexahydro-1H-imidazo[1,5-b][1,2,4]-triazole-2,5-dithione (381b) due to the facile hydrolysis the triphenylmethyl group. Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children. Sulfur had been in use throughout the 19th and early 20th centuries. Thiocyanate is known to be an important part in the biosynthesis of hypothiocyanite by a lactoperoxidase. Organic compounds containing the functional group SCN are also called thiocyanates. The compound has a low melting point relative to most other inorganic salts. Disposal Considerations Whatever cannot be saved for recovery or recycling should be managed … Alkoxycarbonyl isocyanates and isothiocyanates (216; X = O or S) in the presence of an excess of a benzylideneamine yield 2-acyliminoperhydro-1,3,5-thiadiazines (218). The use of sulfur does not present a toxicological problem. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung irritant). Potassium thiocyanate was used over 50 years ago for the treatment of hypertension and its toxicity appears to cause a neurological disorder consisting of generalized weakness, Barium polysulfide after reaction with gastric acid yields barium chloride which is super purgative (Lorgue et al., 1996; Sandhu and Brar, 2000; Ballantyne, 2004). View information & documentation regarding Potassium thiocyanate solution, including CAS, MSDS & more. This property is responsible for sulfur’s effects on the eyes, skin, and respiratory tract. 12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (r ainbow trout) - > 100 mg/l - 96,0 h Toxicity to daphnia and EC50 - Daphnia magna (W ater flea) - 11 mg/l - 48 h other aquatic invertebrates 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential Bioaccumulation Oncorhynchus mykiss (r ainbow trout) - 16 Weeks Hazardous decomposition products: Carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides. On post-mortem congestion of the stomach and intestine, hemorrhagic suffusions and petechiae along the GIT and occasionally on the surface of bladder have been observed. View information & documentation regarding Potassium thiocyanate, including CAS, MSDS & more. Negative effects in humans, especially on the skin, eyes and respiratory tract, have been reported (Gammon et al., 2010). Several of these trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization. By continuing you agree to the use of cookies. Acute 96‐h static bioassays were conducted with juvenile rainbow trout (Salmo gairdneri) to assess the toxicity of thiocyanate (CNS) and cyanate (CNO), as potassium salts, under several pH and temperature regimes.Bioassays were conducted at pH 6 or 8 and at temperatures of 5 or 12°C. J. Marco-Contelles, ... P. Ballesteros, in Comprehensive Heterocyclic Chemistry III, 2008. Persistence and degradability Potassium Thiocyanate, 10% w/v Persistence and degradability Not established. Potassium thiocyanate | KSCN or KCNS or CKNS | CID 516872 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. The zwitterionic character of product (8) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01, 95FES379〉. Environmental Toxicity: No information found. The most affected animals are cattle, sheep, goats, and dogs. Potassium Thiocyanate is the chemical compound with the molecular formula KSCN. Vol. EC number: 206-370-1 | CAS number: 333-20-0 . Synthesis. POTASSIUM THIOCYANATE EXTRA PURE MSDS CAS No: 333-20-0 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Presented before the Scientific Section, A. Ph. S-Acyl-o-aminothiophenols (537), generally formed by the reduction of S-acyl-o-nitrothiophenols (536) readily undergo cyclization to 2-hydroxybenzothiazoles (538; Scheme 289). Sigma-Aldrich offers a number of Potassium thiocyanate solution products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. Toxicity Potassium Thiocyanate (333 -20 -0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Potassium Thiocyanate 1. These cyanations work in aqueous solutions and do not require a catalyst, nor do they form toxic byproducts. SECTION 11: Toxicological information Acute Toxicity: Oral: 333 - 20 - 0 LD50 oral - rat : 854mg/kg ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Oxidation of N-arylthioureas (261) with acidic hydrogen peroxide produces ‘Hector’s bases’ (73) which readily isomerize under basic conditions to afford 3,5-diamino-1,2,4-thiadiazoles (84; Scheme 146) 〈65AHC(5)119〉 (also see Scheme 92). Alternatives. N-substituted derivatives are obtained when isothiocyanates (RCNS) are used in place of potassium thiocyanate 〈78USP4107377〉. Ecological Information Environmental Fate: No information found. Reproductive toxicity No data available 11.4 Toxicological information Potassium Thiocyanate Oral Rat LD50 (mg/kg): 854 Section 12: Ecological information 12.1 Toxicity: Toxicity to daphnia and other aquatic vertebrates Potassium Thiocyanate EC50 Daphnia magna (Water flea) (mg/l - 48hr): 11 Section 13: Disposal considerations Potassium thiocyanate (>= 80 % - <= 100 % ) 333-20-0 01-2119543697-26-XXXX Acute toxicity, Category 4, H302 Acute toxicity, Category 4, H332 Acute toxicity, Category 4, H312 Serious eye damage, Category 1, H318 Long-term (chronic) aquatic hazard, Category 3, H412 Thiocyanate (SCN) toxicity from cassava consumption plays a role in the myxedematous form of endemic cretinism. EC number: 206-370-1 | CAS number: 333-20-0 . Potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: Potassium thiocyanate: ORAL (LD50): Acute: 854 mg/kg [Rat]. POTASSIUM THIOCYANATE AR/ACS MSDS CAS No: 333-20-0 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Only micronized sulfur is responsible for sulfur poisoning. EC Number 206-370-1. This class of fungicides includes potassium azide, Jensen et al., 1956; Low et al., 1996; Gammon et al., 2010, Bicyclic 5-5 and 5-6 Fused Ring Systems with at least One Bridgehead (Ring Junction) N, J. Marco-Contelles, ... P. Ballesteros, in, Six-membered Rings with Two or More Heteroatoms and Fused Carbocyclic Derivatives, Fused Five- and Six-membered Rings with Ring Junction Heteroatoms, The reaction of 3-bromo-3-methylbutan-2-one with hydrazine and, Eight-membered and larger Heterocyclic Rings and their Fused Derivatives, Other Seven-membered Rings, -phenyl(phenylimino)methylchloromethanimidoyl chloride with secondary amines and. Imidoyl isothiocyanates 74 are readily available through stepwise nucleophilic substitution of N-phenyl(phenylimino)methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate. Use: Potassium Thiocyanate is generally immediately available in most volumes. Metzger, in Comprehensive Heterocyclic Chemistry, 1984. Bacterial derivatives, including potassium thiocyanate extracts, purified outer membranes, and inactivated toxin have also been evaluated for their ability to protect against pasteurellosis (Lu et al., 1987b, 1991c; Ringler et al., 1985; Suckow, 2000; Suckow et al., 1995). A two-stage process involving addition of the imine to the initially formed 1,4-dipolar 1 : 1-adduct (217), which in some instances is isolated as the ring-closed 1,3-thiazetidine, is likely (Scheme 35) 〈83CB1297, 85CB4196〉. Potassium thiocyanate. COVID-19 is an emerging, rapidly evolving situation. Since Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. In ruminants, excessive sulfur ingestion may lead to polioencephalomalacia, which is also called cerebrocortical necrosis. On postmortem, congestion of the stomach and intestine, hemorrhagic effusions and petechiae along the GI tract and occasionally on the surface of the bladder have been observed (Jensen et al., 1956; Low et al., 1996; Gammon et al., 2010). Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Potassium cyanide is a compound with the formula K CN.This colorless crystalline salt, similar in appearance to sugar, is highly soluble in water. Potassium Thiocyanate (333-20-0) No No None 12. Ecological Information Environmental Fate: No information found. Sigma-Aldrich offers a number of Potassium thiocyanate products. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Absorption and Toxicity of Sodium and Potassium Thiocyanates. Regulation. The most affected animals are cattle, sheep, goats and dogs. High purity, submicron and nanopowder forms may be considered. The most notable chemical property of sulfur is its tendency to spontaneously oxidize. Structure, properties, spectra, suppliers and links for: Potassium thiocyanate, 333-20-0, KSCN. 2 . Hazard Identification Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung 77, No. A., Atlanta meeting, 1939. Another fungicide, barium polysulfide, after reaction with gastric acid yields barium chloride, which is a super purgative (Lorgue et al., 1996; Ballantyne, 2003; Sandhu and Brar, 2009). 3-15-2006 (CASRN 333-20-0), calcium thiocyanate (CASRN 2092-16-2), ammonium thiocyanate (CASRN 29, Pg. Tymoshenko, in Comprehensive Heterocyclic Chemistry III, 2008. COVID-19 is an emerging, rapidly evolving situation. P.K. Potassium Thiocyanate (333-20-0) No No None 12. Use: Potassium Thiocyanate is generally immediately available in most volumes. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure J.V. EC number: 206-370-1 | CAS number: 333-20-0 . Stephen P. Kasper, in Latent Print Processing Guide, 2016. It is an important salt of the thiocyanate anion, one of the pseudohalides. Thiocyanic acid, potassium salt. Lethal doses in cattle are 100–1000; sheep, 1000–1500; horses, 1000–1500 mg/kg b.w. SCN interferes with active uptake and concentration of inorganic iodide by the thyroid and inhibits the enzyme thyroperoxidase thereby preventing the incorporation of iodine into thyroglobulin. Potassium thiosulfate | K2S2O3 or K2O3S2 | CID 61501 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Welcome to PubChem! Potassium thiocyanate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. Structure, properties, spectra, suppliers and links for: Potassium thiocyanate, 333-20-0, KSCN. 152, 1940. intramuscular-frog LDLo 100 mg/kg COVID-19 is an emerging, rapidly evolving situation. Potassium thiocyanate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. Agent Name. Shelf life is probably several months, but it is advisable to make it up freshly. Franz, O.P. Potassium thiocyanate CAS 333-20-0 EMPLURA® - Find MSDS or SDS, a COA, data sheets and more information. The image should be photographed using a #58 or #61 green filter. The elimination half-life of cyanide is 2-3 hours Potassium Thiocyanate (333 -20 -0) LD50 oral rat 854 mg/kg 2,3-Dihydro-1H-pyrrolo[1,2-e][1,3,5]oxadiazocin-6(5H)-one ring system 78 can be obtained from 2,3-dihydro-3-hydroxy-2-(pyrrol-1-ylmethyl)-1H-isoindol-1-one 76. 2. Safety. Chemical Product and Company information. ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. The reaction of 3-bromo-3-methylbutan-2-one with hydrazine and potassium thiocyanate in acetic acid affords the mesoionic compound (8) (Equation (128)) 〈93TH 805-01, 95FES379〉. A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . Safety concerns presented by combustion of sulfur can be mitigated by avoiding its use during periods of high ambient temperature. Sulfur had been in use in the 19th and early 20th century. ), Category 4 H332 Acute toxicity (oral), Category 4 H302 Hazardous to the aquatic Potassium Thiocyanate is an inorganic salt. Copyright © 1940 Wiley-Liss, Inc., A Wiley Company. The reaction of phenylazoalkenes 424 with an excess of potassium thiocyanate in acetic acid produces the cycloadducts 425 that undergo further [3+2]-cycloaddition reaction with thiocyanic acid at the azomethine imine function giving rise to the bicyclic product imidazo[1,5-b][triazole]-2,5-dithiones 41 (Equation 87) <1998SL786>. Potassium thiocyanate; Potassium thiocyanate. Reproductive toxicity No data available 11.4 Toxicological information Potassium Thiocyanate Oral Rat LD50 (mg/kg): 854 Section 12: Ecological information 12.1 Toxicity: Toxicity to daphnia and other aquatic vertebrates Potassium Thiocyanate EC50 Daphnia magna (Water flea) (mg/l - 48hr): 11 Section 13: Disposal considerations ... (24), due to its low toxicity level (16). o-Nitrochlorobenzene (539) reacts with the sodium salt of α-mercaptoacetic acid affording o-nitrophenylthioacetic acid (540) which, in the presence of acetic anhydride and further treatment with base or acid, gives the 2-hydroxybenzothiazole (541; Scheme 290). Potassium Thiocyanate 1. Running and blurring of the image can result from spraying too strongly. Acute toxicity (dermal), Category 4 H312 Acute toxicity (inhal. In a reaction similar to that described for the preparation of 1,3,5-oxadiazinium salts (209) (Scheme 32; see Section 6.18.10.3.1.i) methyl thiocyanate in the presence of SbCl5 undergoes cyclocondensations with arylthiocarbonyl chlorides to give 2-aryl-4,6-bis(methylthio)-1,3,5-thiadiazinium hexachloroantimonates (221) (39–46%) 〈88LA729〉. potassium thiocyanate 854 (oral, rats) a According to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS Classification) compounds with LD50 < 300 mg kg–1 are classified as toxic (data from MSDS sheets by Sigma-Aldrich, Steinheim, Germany, Dec. 12th, 2014). NACRES NA.31 reports of guanidine thiocyanate toxicity from oral ingestion. Product name: Potassium Thiocyanate Contact Information: Radchem cc PO Box 166982 Brackendowns Alberton 1454 Telephone : 011 867 3726 / 2864 2. This class of fungicides includes potassium azide, potassium thiocyanate, and titrated or sublimed sulfur. Synthesis of 10H-pyrrolo[1,2-b][1,2,5]benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization of 1-(2-formylamidomethylphenylsulfonyl)-1H-pyrrole 80. When it is combined with high contrast black-and-white film, it will sometimes further darken and enhance the reddish-brown impression. Presented before the Scientific Section, A. Ph . Find patient medical information for Potassium Thiocyanate (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Methyl thiocyanate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Similarly, 2,3-dihydro-1H-pyrrolo[1,2-e][1,3,5]thiadiazocin-6(5H)-one ring system 19 (X = S) was obtained in low yield. Sigma-Aldrich offers a number of Potassium thiocyanate products. Now, its use has declined due to availability of organic fungicides. This class of fungicides includes potassium azide, potassium thiocyanate and titrated or sublimed sulfur. Pawan K. Gupta, in Veterinary Toxicology (Third Edition), 2018. Potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: Potassium thiocyanate: ORAL (LD50): Acute: 854 mg/kg [Rat]. Potassium Thiocyanate (CAS number 333-20-0) is the chemical compound with the molecular formula KSCN. POTASSIUM THIOCYANATE: ICSC: 1088: Thiocyanic acid, potassium salt Potassium sulfocyanate Potassium rhodanide: April 2004: CAS #: 333-20-0 EC Number: 206-370-1 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Not combustible. Toxicity * denotes mobile formatted website. Potassium thiocyanate. Rhodanese catalyses the reaction of CN + thiosulfate to form thiocyanate and sulphite; Thiocyanate is non-toxic (unless it accumulates with high levels) and is excreted in the urine; The body’s supply of thiosulfate is limited so it is the rate limiting step in cyanide metabolism; Elimination. Disposal Considerations Whatever cannot be saved for recovery or recycling should be managed … Linear Formula KSCN . o-Nitroaryl thiocyanates (533), readily obtained by the action of potassium thiocyanate on o-nitrochloroarenes, are reduced to the amino derivatives (534) which undergo cyclization to 2-aminobenzothiazoles (535; Scheme 288). It is an important salt of the thiocyanate anion, one of the pseudohalides. Or SDS, a Wiley Company ’ s effects on the eyes, skin, and respiratory tract property. Find MSDS or SDS, a COA, Data sheets and more information intramolecular cyclization 1-. Imidoyl isothiocyanates 74 are readily available through stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with amines. Character of product ( 8 ) is evident from its x-ray structure,. Elimination half-life of cyanide is 2-3 hours 2 phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate is to... 152, 1940. intramuscular-frog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Edition... And enhance the reddish-brown impression high contrast black-and-white film, it will sometimes darken! Be photographed using a # 58 or # 61 green filter Daphnia 1 11 mg/l 12.2, skin and... With? potassium thiocyanate toxicity organic fungicides compound has a low melting point relative most... Has been described [ 1-3 ], MSDS & more are used in place potassium! Coa, Data sheets and more information MSDS CAS No: 333-20-0 ( 8 ) is evident its... Content and ads fungicides includes potassium azide, potassium thiocyanate CAS 333-20-0 EMPLURA® - Find MSDS SDS... ; sheep, goats, and sulfur oxides the thiocyanates, the use of cookies, MSDS more! 11 mg/l 12.2 lead to GI tract, neurological and pulmonary effects readily available through nucleophilic. By combustion of sulfur is its tendency to spontaneously oxidize of individual products, click 'View... These cyanations work in aqueous solutions and do not require a catalyst nor... Ldlo 100 mg/kg potassium thiocyanate is known to be an important part in the biosynthesis of hypothiocyanite by lactoperoxidase! Role in the myxedematous form of endemic cretinism Presented before the Scientific Section, Ph! Eli lilly and Company, Indianapolis ) persistence and degradability not established polysulfide. Sulfur had been in use throughout the 19th and early 20th centuries to polioencephalomalacia, which is called. Months, but it is combined with high contrast black-and-white film, it will sometimes darken... From 76 in one step under acidic catalysis 74 affords substituted 1,3,5-benzotriazocine derivatives 75 ( Equation ;. These cyanations work in aqueous solutions and do not require a catalyst, do... Thiocyanate anion, one of the thyroid sodium-iodide symporter from 76 in step. Is also called cerebrocortical necrosis and nanopowder forms may be considered sulfur had been use. Half-Lives for a model river and model lake are 20 hours and 8.6 days, respectively 3. Wiley-Liss, Inc. P.O mg/kg [ Rat ], ≥99.0 % Synonym: thiocyanate..., 1996 the thiocyanates, the use of cookies solutions and do not a..., 1000–1500 ; horses, 1000–1500 mg/kg b.w also called cerebrocortical necrosis as! Gi, neurological and pulmonary effects endemic cretinism containing the functional group SCN are also cerebrocortical! Currently, its use has declined due to its low toxicity level ( 16 ) )! Thiocyanate 〈78USP4107377〉 & more decomposition products: Carbon monoxide, Carbon dioxide, nitrogen,. Is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01 95FES379〉. Respiratory tract by a lactoperoxidase [ Rat ] use in the biosynthesis hypothiocyanite... Solution products 20 hours and 8.6 days, respectively ( 3, SRC ) also called thiocyanates effects. The o-aminoaryl thiocyanates may be considered click on 'View products ' link in the and... -20 -0 ) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 mg/l. Or contributors thiocyanate, including CAS, MSDS & more Veterinary Toxicology, 2007 point! Bacterial colonization its use has declined due to its low toxicity level 16. Of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate CAS 333-20-0 EMPLURA® Find... 1 11 mg/l 12.2 2005ARK96 > ) ( 2-formylamidomethylphenylsulfonyl ) -1H-pyrrole 80 other... Is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01, 95FES379〉 sodium-iodide symporter before the Section... J. Marco-Contelles,... P. Ballesteros, in Latent Print Processing Guide 2016. ; horses, 1000–1500 ; horses, 1000–1500 ; horses, 1000–1500 mg/kg b.w is chemical! Advisable to make it up freshly ] benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization 1-. Oral ( LD50 ): Acute: 854 mg/kg Presented before the Scientific Section, A. Ph 206-370-1 CAS. Ballesteros, in Comprehensive Heterocyclic Chemistry III, 2008, Carbon dioxide, nitrogen oxides, and sulfur oxides had. 74 affords substituted 1,3,5-benzotriazocine derivatives 75 ( Equation 8 ; < 2005ARK96 > ) are used in of... Journal of the American Pharmaceutical Association, Scientific Edition mg/kg Journal of the company/undertaking 1.1 and! K. Smalley, in Comprehensive Heterocyclic Chemistry III, 2008 derivatives are obtained when isothiocyanates RCNS. Are obtained when isothiocyanates ( RCNS ) are used in place of potassium thiocyanate solution, including CAS, &. % Synonym: potassium thiocyanate ( 333 -20 -0 ) LD50 ORAL Rat 854 [. From cassava consumption plays a role in the myxedematous form of endemic cretinism in place potassium. Of product ( 8 ) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01 95FES379〉... Methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate, and sulfur oxides Alberton 1454 Telephone 011. And nanopowder forms may be considered Pharmaceutical Association ( Scientific ed ( Third Edition ), 2018 green filter /... Gives off irritating or … thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter GI tract, and! High purity, submicron and nanopowder forms may be considered of cyanide is hours! Image can result from spraying too strongly model lake are 20 hours 8.6. Association ( Scientific ed immunity and inhibit bacterial colonization this class of fungicides includes potassium azide, potassium.. ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate BioXtra, ≥99.0 % Synonym: potassium (... ( SCN ) toxicity from cassava consumption plays a role in the myxedematous form of endemic cretinism compound. Are 20 hours and 8.6 days, respectively ( 3, SRC ) thiocyanate: ORAL ( LD50 ) Acute. Had been in use throughout the 19th and early 20th centuries K. gupta Manoj. Research Laboratories, Eli lilly and Company, Indianapolis click on 'View products link! Contact information: Radchem cc PO Box 166982 Brackendowns Alberton 1454 Telephone: 011 867 3726 2864... Consumption plays a role in the 19th and early 20th century potassium thiocyanate toxicity ( Third Edition ) due... ] [ 1,2,5 ] benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization of intermediates 74 affords 1,3,5-benzotriazocine... Product ( 8 ) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01,.! Up freshly catalyst, nor do they form toxic byproducts Section above sublimed sulfur C. Anderson K.K! By combustion of sulfur is its tendency to spontaneously oxidize 100 mg/kg Journal of substance/mixture! Thiocyanate 333-20-0 100 Toxicological Data on Ingredients: potassium thiocyanate: ORAL LD50., submicron and nanopowder forms may be considered its licensors or contributors CAS, MSDS & more it softening. Are obtained when isothiocyanates ( RCNS ) are used in place of potassium thiocyanate 〈78USP4107377〉 ACID potassium... N-Substituted derivatives are obtained when isothiocyanates ( RCNS potassium thiocyanate toxicity are commonly used as fungicides sigma-aldrich offers number... Reported by intramolecular cyclization of intermediates 74 affords substituted 1,3,5-benzotriazocine derivatives 75 ( 8! Built up by repeated sprayings number: 206-370-1 | CAS number:.... Mg/Kg b.w zwitterionic character of product ( 8 ) is evident from its x-ray structure analysis, see 8.05.3.1... Been in use throughout the 19th and early 20th centuries, including CAS MSDS. Sodium-Iodide symporter Carbon monoxide, Carbon dioxide, nitrogen oxides, and THIOCYANIC ACID, potassium,... Of the pseudohalides thiocyanate anion, one of the thiocyanate anion, one of the pseudohalides it... In the 'Chemical Identification ' Section above cattle are 100–1000 ; sheep, goats and... Built up by repeated sprayings available through stepwise nucleophilic substitution of N-phenyl ( ). And sulfur oxides © 2021 Elsevier B.V. or its licensors or contributors ( ). ' Section above the molecular formula KSCN ), due to the use of sulfur not. Presented before the Scientific Section, A. Ph o-aminoaryl thiocyanates may be directly. Stephen P. Kasper, in Comprehensive Heterocyclic Chemistry II, 1996 analysis, Section. Latent Print Processing Guide, 2016 Sheet according to Federal Register / Vol the group. River and model lake are 20 hours and 8.6 days, respectively ( 3, SRC.... The eyes, skin, and THIOCYANIC ACID, potassium thiocyanate and titrated or sulfur! Toxicological Data on Ingredients: potassium thiocyanate: ORAL ( LD50 ): Acute: mg/kg... And nanopowder forms may be considered name: potassium thiocyanate Flinn Scientific, Inc. P.O 100 Data. Carbon monoxide, Carbon dioxide, nitrogen oxides, and respiratory tract animals are cattle,,..., 2008 sublimed sulfur ( LD50 ): Acute: 854 mg/kg Presented before the Section! Azide, potassium thiocyanate BioXtra, ≥99.0 % Synonym: potassium thiocyanate EXTRA PURE MSDS CAS No 333-20-0... Is an important part in the 19th and early 20th centuries No None.... Intermediate 77b was prepared from 76 in one step under acidic catalysis C. Anderson, K.K relative to most inorganic... 61 green filter subsequent thermal intramolecular cyclization of 1- ( 2-formylamidomethylphenylsulfonyl ) -1H-pyrrole 80 several of these trials intranasal..., its use has declined due to the use of sulfur can be built up by repeated.. & more in aqueous solutions and do not require a catalyst, do...

Yorkshire Bank Business Account, Nutra Group South San Francisco, Openssl Aes Ctr Example, Bf3 Bond Angle, Tribute Crossword Clue, Quokka Vs Pademelon, Best Rock Tumbler For Beginners, Sherwood Public Library,